Process for the manufacture of metal salts of sulpho-arsenol



Patented June 26, 1928.

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rRooEss FOR THE MANUFACTURE or MErrAnsn Ts oFs LrHo-ARsnNoL,

No Drawing. Original application filed May as, 1924, e No 716/ 182.

.. filed November 9, 1925; Serial No. 68,011.

The present application 'is .a division of my application No. 716,482filed May 28th, 1924:.

It is known that by reacting arsphenamine or neoarsphenamine (3,3-diamino-4, l d hydroxyarsenobenzene or sodium 3.3 -d1am1no- 4, 4dihydroxyarsenobenene N methylene sulphonate), with ametallic salt ofsuitable electropolarity, complex arsenometallic compounds are obtained,which are more active than arsphenamine or neoarsphenamine. I

But'the bodies thus obtained present various disadvantages, among whichare the 'following: they are not very. stable, they are easilyoxidizable and their toxicity is largely increased. Moreover, when theyare used as medicines, they can only be employed for intravenous use andnot for sub-cutaneous use. I

The present invention has for its object to obtain organo-metallicproducts containing arsen ob enzene as the main ingredient but which donot possess these drawbacks (par: tic-ularly to obtain products whichare much less toxic than those derived from arsphenamine andneoarsphenamine, and capable to be applied under the skin). 7

For that purpose it consists substantially in combining a solublemetallic salt with arsphenamine base afterthe transformation of thelatter into sulpho-arsenol (3, 3- diamino 4, 4t dihydroxyarsenobenzeneN- methylene sulphonate of sodium). The resulting substance represents acomplexmetallie compound ofsulpharsenol, with the I 7 metal attached, tothe arseno group.

The invention comprises reacting the soluble salt of the desired metalwith sulphoarsenol itself.

A complex organo-metallic derivative of sulpho-arsenol is obtained,presenting the following main advantages:

1. It is notcaustic; it is perfectly neutral P and does not injure theliving tissues.

2. Its toxicity is much reduced and is from 4a to 10 times less thanthat ofthe original products. y I

3. It does not readily oxidize. Solutions of it therefore do not rapidlybecome toxic when exposed to air.

The example hereinafter set forth will give a clear understanding oft-heprocess.

EwampZe.The zinc sulphoarsenol is obtained by dissolving one to twomolecular weights of bichloride of zinc or other salt of 'zinc solublein methyl alcohol or fractions Divided and this application" 7 ofmolecularaveights if it is desired to pre- I pare products containingless zinc, in 10 parts of alcohol, and, on the other hand, a molecularweight of sulpho-arsenol in 2 parts of water.

The alcohol solution slowly poured into the solution of sulpho-arsenolwhile cooling;

the precipitation of the salt'sets in at once,

. Normal alcoholic caustic soda is added, until nearly neutral, and thewhole is left to settle 24 hours, then. filtered and washed withpurealcohol from impurities (chloride of sodium,

hydrochloric acid, free sulphurous acid).

The product is a complex metallic compound in which the zinc attachesitself to the arseno-group' the alkaline salt,that is 'themethylsulphonate of sodium remains untouched.

The product obtained is in the form of a lightyellow powder soluble inwater in any proportions, giving a very light yellow solut'ion,insoluble in the usual organic mediums;

Ammonia and the alkaline reagents darken the colour of the solutionwithout releasing the zinc. r

on on chlorides (and other soluble salts of these metals) are essentialpoints of the'invention.

It is to be understood that all the details for carrying out the processcan be varied in all cases without departing from the "principle of theinvention.

I Claimsi 1. A process for the manufacture of com plex metal compoundsof sulpharsenolwhich comprises combining a soluble metallic salt withsulpharsenol.

2. A process for the manufacture of organo-metallic combinations ofsulpharsenol which comprises combining soluble metallic chlorides withsulpharsenol.

3. The process for the manufacture of complex zinc compound salts ofsulpharsenol which comprisee treating sulpharsenol with zinc chloride.

4L. A process for the manufacture of zinc complex compounds ofsulpharsenol which comprises treating a solution of a zinc salt withsulpharsenol.

5. A Zinc compound of sulpharsenolwith the probable formula gmAS INa.SOa-CH2 .NIIO I NH.CH .SO iNa I I 20 OH OH Signed by me this 30th dayof October, 1925.

FREDERIC LEHNHOFF VYLD.

